Accurate Measurement of Free Drug Concentrations
Accurate Measurement of Free Drug Concentrations
September 15 2017
TAGS: ChemistryTheoretical-licensingLife SciencesPhysical SciencesMath/Statistics
September 15 2017 13:15 UTC
The drug discovery process is driven by a series of in vitro and in vivo assays to inform the optimization of drug candidates with the ultimate goal of achieving therapeutic efficacy. The percent of total drug present that is not bound to proteins or other cellular components (i.e., the free drug concentration) is thought to correlate with a compound’s pharmacological activity. Therefore, the Seeker is searching for a novel, non-destructive approach for the precise and accurate measurement of free drug concentrations in target tissues.
Challenge Overview